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How to Treat MRSP in Dogs: Best Practices

How to Treat MRSP in Dogs: Best Practices

Infection

10 min read

Learn how to treat MRSP in dogs with vet-approved methods. Explore symptoms, best treatments, & prevention tips to manage antibiotic-resistant infections

By 

Sustainable Vet Group

Updated on

March 11, 2025

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Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is a bacterial infection in dogs that doesn't respond to many antibiotics. It is related to MRSA (methicillin-resistant Staphylococcus aureus), which affects humans. MRSP often leads to skin infections, ear infections, and, in severe cases, deep tissue infections.

The biggest challenge with MRSP is its antibiotic resistance. Common antibiotics like penicillins and cephalosporins don't work against this bacteria. This resistance happens because of the overuse or misuse of antibiotics, making infections harder to treat. Treatment options are limited to specific, carefully chosen antibiotics or alternative therapies.

Signs Your Dog Might Have MRSP

Dogs with MRSP may show persistent skin infections that do not respond to regular antibiotics. Symptoms include:

  • Red, inflamed skin with sores or pustules
  • Excessive itching and hair loss
  • Recurrent ear infections with discharge
  • Slow-healing wounds
  • Swelling or pain in the affected area

If your dog shows these signs, a veterinary diagnosis with bacterial culture testing is crucial for proper treatment.

Treatment Options for MRSP in Dogs

Home Care & Infection Control (Immediate Actions)

When dealing with MRSP, preventing the spread of bacteria is just as important as treating the infection. Since MRSP is resistant to many antibiotics, proper hygiene and containment measures can help protect other pets and humans in the household.

  • Isolate the infected dog: Keep your dog separated from other pets to prevent bacterial transmission. MRSP can spread through direct contact, shared items, or contaminated surfaces.
  • Practice strict hygiene: Always wash your hands thoroughly with soap and water after handling your dog. Use disposable gloves if treating wounds.
  • Disinfect frequently used items: Clean bedding, collars, leashes, bowls, and any surfaces your dog touches using pet-safe disinfectants. Wash fabric items in hot water and dry them completely.
  • Prevent self-trauma: Dogs with MRSP infections often scratch or lick the affected area, worsening the infection. Use an e-collar (Elizabethan collar) or protective clothing to prevent irritation and reinfection.

Proper infection control begins in the operating room, and if a veterinary surgeon uses an advanced wound irrigation solution like Simini Protect Lavage during surgery, it can help reduce bacterial contamination, including MRSP, lowering the risk of post-operative infections.

Topical Therapy (First-Line Treatment)

Topical therapy is a crucial first step in managing MRSP infections. Since MRSP bacteria live on the skin, direct application of antiseptics and antibiotics can help reduce bacterial load and promote healing.

  • Antiseptic baths: Bathe your dog 2–3 times per week using an antiseptic shampoo containing 2–4% chlorhexidine. This helps kill bacteria on the skin and prevent new infections. Allow the shampoo to sit on the coat for 10 minutes before rinsing thoroughly.
  • Mupirocin ointment: Apply twice daily to small, localized MRSP lesions. Mupirocin is effective against Staphylococcus pseudintermedius and helps treat infected wounds or hot spots.
  • Topical amikacin spray: This antibiotic spray can be used once or twice daily to control bacterial growth in severe or widespread infections. It is often recommended when oral antibiotics are not an option.

Consistency is key—continue treatment for at least 2–4 weeks or as directed by your veterinarian. If symptoms persist or worsen, further medical intervention may be necessary.

Systemic Antibiotic Therapy (For Severe Cases)

Systemic antibiotics should be used only when necessary, as MRSP is resistant to many common antibiotics. Overuse can lead to further resistance, making future infections even harder to treat. In mild cases, topical therapy alone may be enough.

  • Culture and sensitivity testing: Before starting any antibiotic, a veterinarian should perform a bacterial culture and sensitivity test. This identifies which antibiotics are effective against the specific MRSP strain in your dog. Treating without testing can lead to failed therapy and stronger resistance.
  • Avoid beta-lactam antibiotics: Penicillins and cephalosporins are ineffective against MRSP and should not be used. This includes commonly prescribed antibiotics like amoxicillin-clavulanate or cephalexin.
  • Alternative antibiotic options: Depending on test results, chloramphenicol, aminoglycosides (amikacin), clindamycin, or doxycycline may be prescribed. These are not first-line antibiotics and should only be used under veterinary guidance due to possible side effects.

Systemic antibiotic therapy typically lasts 4–6 weeks and requires strict follow-up to monitor effectiveness. If symptoms persist, adjusting the treatment plan may be necessary.

Duration of Treatment (How Long to Continue)

The duration of treatment for MRSP infections depends on the severity and depth of the infection. Stopping treatment too early can lead to recurrence, making the infection harder to eliminate in the future.

  • Superficial pyoderma: This is a mild to moderate skin infection affecting the outer layers of the skin. Treatment with topical therapy and, if necessary, systemic antibiotics should continue for at least 3 weeks or one week beyond visible healing.
  • Deep pyoderma: If the infection has spread into deeper skin layers, treatment is more intensive. Therapy should last 4–8 weeks or longer, continuing for at least 1–3 weeks after all lesions have healed to prevent relapse.

Why is extended treatment necessary? MRSP is highly resistant, and stopping treatment too soon allows surviving bacteria to multiply, leading to reinfection. This can also make the bacteria more difficult to treat in the future.

Regular veterinary check-ups and follow-up cultures help ensure the infection is fully cleared before stopping treatment.

Supporting Your Dog’s Recovery at Home

Diet & Supplements to Boost Healing

A nutrient-rich diet and targeted supplements can strengthen your dog's immune system and support skin healing after an MRSP infection. Proper nutrition plays a crucial role in reducing inflammation, repairing the skin barrier, and preventing future infections.

  • Omega-3 supplements: Fish oil rich in EPA and DHA helps reduce inflammation and promote healthy skin. These essential fatty acids improve the skin barrier, making it more resistant to bacterial infections.
  • Probiotics: If your dog has been on antibiotics, adding probiotics helps restore gut balance and support immune function. Look for Lactobacillus and Bifidobacterium strains, which promote good digestion and reduce antibiotic-related side effects.
  • Hyaluronic acid sprays: Topical hyaluronic acid (HA) sprays enhance skin hydration and barrier repair, reducing irritation and supporting wound healing. They also help create a protective layer, preventing bacteria from re-entering the skin.

Feeding a high-quality, protein-rich diet with these supplements can help your dog recover faster and build long-term resistance against skin infections. Always consult your veterinarian before adding supplements to your dog’s routine.

Hygiene & Environmental Adjustments

Creating a clean, bacteria-free environment is essential to prevent reinfection and support your dog’s recovery from MRSP. Since MRSP can survive on surfaces, proper hygiene and environmental control help minimize bacterial spread.

  • UV sterilization wands: These devices eliminate bacteria, viruses, and fungi on surfaces like bedding, collars, leashes, and food bowls. UV-C light disrupts bacterial DNA, making it an effective chemical-free disinfection method.
  • Air purifiers with HEPA filters: MRSP bacteria can spread through air and dust particles. Using an air purifier with a HEPA filter helps capture airborne bacteria and allergens, reducing the risk of reinfection.
  • Regular grooming: Keeping your dog’s skin clean is key. Bathe them with antimicrobial shampoos as recommended and brush their coat regularly to remove dirt, dead skin cells, and bacteria. Clean ears, trim nails, and check for any signs of skin irritation.

By maintaining strict hygiene practices and a clean home environment, you can lower bacterial exposure and help your dog heal faster.

Preventing Future MRSP Infections

Preventing reinfection is crucial for dogs that have recovered from MRSP. Since MRSP bacteria can persist in the environment and on the skin, consistent hygiene, early monitoring, and veterinary follow-ups are essential to keep your dog healthy.

  • Regular bathing and hygiene: A weekly or biweekly bath with antiseptic shampoos (2–4% chlorhexidine) helps control bacterial levels on the skin. Regular cleaning of bedding, food bowls, and grooming tools prevents contamination.
  • Monitoring for early signs: Dogs prone to skin infections should be checked regularly for redness, bumps, hair loss, or excessive scratching. Catching infections early allows for faster treatment with topical antiseptics, reducing the need for systemic antibiotics.
  • Routine veterinary checkups: If your dog has a history of MRSP or recurrent skin infections, schedule regular checkups every 3–6 months. Your vet can perform skin cultures or cytology to detect bacteria before a full-blown infection develops.

By staying proactive with hygiene, early intervention, and veterinary care, you can significantly reduce the risk of future MRSP infections and keep your dog’s skin healthy.

When to See a Veterinarian

While home care and prescribed treatments can help manage MRSP infections, some cases require immediate veterinary attention. If your dog’s condition does not improve or worsens, a veterinarian can reassess the treatment plan to prevent complications.

  • No improvement after 2 weeks: If your dog is receiving topical or systemic treatment but the infection persists after 2 weeks, it may indicate treatment resistance. A vet may need to adjust the antibiotic plan based on a new culture and sensitivity test.
  • Worsening or spreading infection: If redness, swelling, or sores continue to spread despite home care, the infection could be deepening. MRSP can sometimes penetrate deeper tissues, leading to cellulitis or abscess formation, which requires stronger medical intervention.
  • Systemic illness signs: If your dog becomes lethargic, refuses food, or develops a fever, the infection may have entered the bloodstream (sepsis) or caused a secondary illness. This is a medical emergency requiring urgent veterinary care.

Early veterinary intervention can prevent severe complications, ensuring a faster and safer recovery for your dog.

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Conclusion

Treating MRSP in dogs involves a thorough approach, combining home care, topical treatments, and, in severe cases, systemic antibiotics. Quick infection control, good hygiene, and using antiseptic shampoos, mupirocin ointment, or amikacin spray can help manage mild cases. For deeper infections, antibiotics prescribed by a vet should be used based on culture and sensitivity tests to prevent resistance.

It's important to complete the entire treatment course—stopping early can lead to reinfection and antibiotic resistance. For surface infections, treatment should last at least 3 weeks, while deeper infections may need 4–8 weeks or more.

If your dog's condition does not improve or gets worse, consult a veterinarian right away. Regular checkups and early intervention can help prevent complications. By being proactive and following the right treatment steps, you can ensure a full recovery and lower the risk of future MRSP infections. Always seek veterinary advice for the best results.

FAQs

What Are the Symptoms of MRSP in Dogs?

MRSP infections in dogs typically cause persistent skin issues that do not respond to standard antibiotics. Common symptoms include red, inflamed skin, sores, pustules, hair loss, and excessive itching. Dogs may also experience chronic ear infections, slow-healing wounds, and pain or swelling in affected areas. In severe cases, MRSP can spread to deeper tissues, leading to systemic illness requiring urgent veterinary care.

Can MRSP in Dogs Be Cured?

Yes, MRSP infections can be effectively managed with proper treatment, but complete elimination depends on the severity. Topical antiseptics, targeted antibiotics (if needed), and strict hygiene help control the infection. Since MRSP is resistant to many antibiotics, culture and sensitivity testing is crucial for choosing the right medication. Long-term management, including regular checkups and preventive care, is necessary to reduce the risk of recurrence.

Is MRSP in Dogs Contagious to Humans?

Yes, MRSP can be zoonotic, meaning it can spread from dogs to humans, though the risk is low for healthy individuals. People with weakened immune systems, such as the elderly or those with chronic illnesses, are at higher risk. Proper hygiene, including handwashing after handling an infected dog, is essential to reduce the risk of transmission. Close contact, such as sleeping in the same bed, should be avoided.

Can MRSP in Dogs Go Away Without Treatment?

No, MRSP infections do not resolve on their own. Since MRSP is resistant to many antibiotics, untreated infections can worsen and spread. Some cases may respond to topical antiseptics and improved hygiene, but veterinary treatment is often necessary. Without proper care, the infection can persist for months, leading to chronic skin issues and potential systemic complications. Seeking veterinary guidance is essential.

How Long Does It Take for a Dog to Recover from MRSP?

Healing time depends on the severity of the infection and the treatment approach. Superficial infections typically improve within 3 weeks, while deep infections require 4–8 weeks or longer of continuous treatment. Treatment must continue for 1–3 weeks after visible healing to prevent recurrence. Regular follow-ups and bacterial cultures ensure the infection is fully resolved before stopping treatment.

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Step #1

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Ensuring a clean surgical field starts with proper skin preparation. This video demonstrates the best practices for:

  • Shaving the patient – Achieving a close, even shave while minimizing skin irritation
  • The Dirty Scrub – The initial skin prep step to remove surface debris and reduce bacterial load before the sterile scrub.

Following these techniques helps reduce infection risk and improve surgical outcomes. Watch the video to see how it’s done effectively!

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Preventing surgical infections is critical for patient safety and successful outcomes. This course covers:

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