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Staph Infection After TPLO Surgery: Signs & Risks

Staph Infection After TPLO Surgery: Signs & Risks

TPLO

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Staph infections after TPLO surgery can cause serious issues. Learn how to spot early symptoms, treat infections, and prevent complications

By 

Sustainable Vet Group

Updated on

March 5, 2025

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A Staph infection after TPLO surgery is a bacterial infection caused by Staphylococcus species at the surgical site. These infections happen when bacteria enter the incision, leading to inflammation, pain, swelling, and, in severe cases, delayed healing or implant issues.

The most common bacteria involved are

  • Staphylococcus pseudintermedius (S. pseudintermedius is naturally found on a dog's skin and can become problematic after surgery.)
  • Staphylococcus aureus (S. aureus is less common in dogs but can still cause serious infections, sometimes resistant to antibiotics like MRSA.)

TPLO surgeries are particularly prone to infection because of the metal implants, which provide a surface for bacteria to stick to and form biofilms. Additionally, open incisions, surgical trauma, and a dog's licking or scratching increase the risk of infection.

Using proper sterile techniques, taking care of the wound after surgery, and detecting infections early are crucial for preventing complications and ensuring a smooth recovery.

TL;DR

  • Staph infections after TPLO surgery are rare but can happen, with Staphylococcus pseudintermedius being the most common culprit.
  • Early treatment with antibiotics is crucial as infections typically won't heal on their own and can lead to serious complications.
  • Untreated infections may cause osteomyelitis, implant failure, or systemic illness, requiring more invasive treatments.
  • Proper post-op care and monitoring the incision site are key to preventing infections.
  • If an infection is severe, the TPLO plate may need to be removed to prevent further complications.

Causes of Staph Infection After TPLO Surgery

Staph infections after TPLO surgery occur when Staphylococcus bacteria enter the surgical site, multiply, and trigger an inflammatory response. These infections can develop due to various factors, often related to contamination, improper wound care, or the dog's overall health.

Surgical Site Contamination - Even with strict sterile protocols, bacteria from the skin, surgical instruments, or operating room can enter the incision. Staphylococcus pseudintermedius is naturally found on a dog's skin and may infect the site if proper antiseptic measures are not followed.

Improper Wound Care - After surgery, poor wound management increases infection risk. If bandages are not changed regularly, the incision is exposed to dirt, or the dog licks the wound, bacteria can enter. Delayed healing also creates an opportunity for bacterial overgrowth.

Weakened Immunity - Dogs with weakened immune systems due to age, chronic illnesses (like diabetes or Cushing’s disease), or prolonged use of immunosuppressive medications are more vulnerable to infections. Their bodies struggle to fight bacteria, increasing the risk of severe complications.

Hospital-Acquired vs. Environmental Bacteria - Hospital-acquired infections, often resistant to antibiotics (e.g., MRSA), pose a serious threat. Environmental bacteria, from bedding, floors, or other animals, can also infect wounds if hygiene is inadequate. Proper post-op care and monitoring are essential for prevention.

Risk Factors for Developing Infections Post-TPLO

Several factors increase the risk of Staph infection after TPLO surgery, including dog-related, surgical, and post-op care factors. Understanding these risks helps in preventing complications and ensuring a smooth recovery.

Dog-Related Factors

Certain dogs are more prone to infections. Older dogs, immunocompromised pets (diabetes, Cushing’s disease), and breeds with skin folds (like Bulldogs) are at higher risk due to weaker immune defenses or bacterial colonization. Overweight dogs also have reduced blood flow to the incision, slowing healing.

Surgical Factors

Implant contamination is a major concern, as metal plates provide a surface for bacteria to form biofilms, making infections harder to treat. Prolonged surgery times, non-sterile conditions, and inadequate antibiotic prophylaxis increase infection risk.

To minimize this, many surgeons use Simini Protect Lavage, a non-antibiotic surgical lavage that helps reduce bacterial contamination and biofilm formation on implants, lowering the chances of post-op infections.

Post-Op Care Factors

Excessive licking, poor hygiene, and delayed wound healing significantly raise infection risks. Dogs licking their incision introduce bacteria, while unclean bedding and surroundings expose wounds to environmental contaminants. Owners must follow strict post-op wound care guidelines and monitor for early signs of infection.

Symptoms of a Staph Infection After TPLO Surgery

Recognizing the early signs of Staph infection after TPLO surgery is crucial for timely treatment. Infections can range from mild to severe, potentially leading to implant complications or systemic illness if left untreated.

Early Signs - In the initial stages, the infection may cause redness, swelling, and warmth around the incision site. Mild discomfort is normal post-surgery, but persistent inflammation or increasing pain could indicate bacterial activity. Some dogs may start licking or chewing the incision, further worsening the condition.

Moderate Symptoms - As the infection progresses, pus or thick discharge may develop, often accompanied by a foul odor. The incision may start to separate or appear moist and inflamed. Dogs might also show signs of discomfort, such as limping, stiffness, or reluctance to bear weight on the affected leg. These symptoms suggest that the infection is spreading deeper into the tissue.

Severe Symptoms - In advanced cases, the infection can lead to systemic illness, causing fever, lethargy, loss of appetite, and general weakness. If bacteria spread to the bone or implant, it can result in implant loosening or failure, requiring urgent medical intervention. Immediate veterinary attention is needed to prevent complications and ensure proper healing.

How Staph Infections Are Diagnosed After TPLO Surgery

Diagnosing a Staph infection after TPLO surgery requires a thorough veterinary examination, laboratory tests, and sometimes imaging to assess the severity of the infection and its impact on the surgical site.

Veterinary Examination and Wound Assessment

A veterinarian will start by visually inspecting the incision site for signs of infection, such as redness, swelling, pus, or a foul odor. They will also check for pain, heat, and any abnormal discharge. If the dog is limping, lethargic, or showing signs of discomfort, it may indicate a deeper infection affecting the bone or implant.

Lab Tests: Bacterial Culture and Antibiotic Sensitivity

To confirm a Staph infection, a bacterial culture is performed by collecting a sample from the infected area. This test identifies the specific bacteria causing the infection, typically Staphylococcus pseudintermedius or Staphylococcus aureus.

Antibiotic sensitivity testing is then conducted to determine which antibiotics will be most effective, especially important for resistant strains like MRSP (Methicillin-Resistant Staphylococcus pseudintermedius).

Imaging Methods for Implant-Associated Infections

If an infection is suspected to have spread to the bone or implant, X-rays or advanced imaging like CT scans may be used. These help detect signs of bone lysis, implant loosening, or deep tissue infection, which could require additional surgical intervention. Early diagnosis is crucial to prevent complications and improve treatment outcomes.

The Role of Multidrug-Resistant Bacteria in TPLO Infections

One of the biggest challenges in treating Staph infections after TPLO surgery is the presence of multidrug-resistant bacteria, particularly Methicillin-Resistant Staphylococcus pseudintermedius (MRSP). This bacterial strain has developed resistance to many commonly used antibiotics, making infections harder to treat and increasing the risk of complications.

What is MRSP?

MRSP is a resistant form of Staphylococcus pseudintermedius, a bacterium normally found on a dog’s skin. In healthy dogs, it rarely causes issues, but after TPLO surgery, it can infect the surgical incision and implants, leading to persistent infections. MRSP is similar to MRSA (Methicillin-Resistant Staphylococcus aureus) in humans, making it difficult to eliminate with standard antibiotics.

Why Traditional Antibiotics May Not Work

Since MRSP is resistant to beta-lactam antibiotics (penicillins and cephalosporins), commonly prescribed antibiotics may be ineffective. Inappropriate antibiotic use can worsen resistance, making treatment options more limited. Infected implants and biofilm formation further protect the bacteria, requiring alternative treatments.

Impact on Treatment Complexity and Recovery Time

Resistant infections prolong recovery, as stronger antibiotics, prolonged treatment, or even implant removal may be necessary. In severe cases, advanced antimicrobial therapies, surgical debridement, or alternative infection-control measures like Simini Protect Lavage may be required to manage the infection and prevent recurrence. Early culture and sensitivity testing is essential for selecting the most effective treatment.

How Biofilms on Implants Worsen Staph Infections

Biofilms are colonies of bacteria that form a protective layer on surfaces, such as TPLO plates and screws. In post-surgical infections, Staphylococcus pseudintermedius and other bacteria can attach to the metal implant, creating a slimy, protective matrix that shields them from antibiotics and the immune system.

How Biofilms Form on TPLO Implants

After TPLO surgery, bacteria from the skin, surgical instruments, or environment can adhere to the implant. Once attached, they produce a sticky extracellular substance, allowing them to grow and form a dense bacterial community. These biofilms anchor bacteria to the implant surface, making infections harder to eradicate.

Why Biofilms Resist Antibiotics and Immune Responses

Biofilms create a physical and chemical barrier that prevents antibiotics from fully reaching the bacteria. Additionally, bacteria within biofilms enter a dormant state, reducing their susceptibility to drugs that typically target active bacterial growth. The immune system also struggles to clear biofilms, as white blood cells cannot penetrate the bacterial layer effectively.

Treatment Challenges and Surgical Interventions

Because biofilm-associated infections are difficult to treat, prolonged antibiotic therapy alone is often ineffective. In severe cases, surgical debridement or implant removal may be required.

Many surgeons use Simini Protect Lavage during TPLO procedures to reduce bacterial adhesion and biofilm formation, helping to lower the risk of persistent infections.

Complications of Staph Infection After TPLO Surgery

A Staph infection after TPLO surgery can lead to severe complications if not treated promptly. The presence of metal implants, biofilm formation, and antibiotic-resistant bacteria make these infections particularly challenging.

  • Implant Rejection or Failure - When bacteria colonize the TPLO plate, they can cause loosening of the implant, preventing proper bone healing. The immune system may recognize the infection as a foreign threat, triggering chronic inflammation and implant rejection. In severe cases, implant removal and revision surgery are required.
  • Chronic Infections Leading to Osteomyelitis - Untreated or persistent infections can spread to the bone, causing osteomyelitis (bone infection). This condition leads to bone destruction, pain, and ongoing inflammation. Osteomyelitis often requires long-term antibiotics, surgical debridement, and sometimes implant removal to eliminate infected tissue.
  • Increased Surgical Costs and Prolonged Recovery - Managing an infection often involves extended hospitalization, additional lab tests, imaging, and stronger antibiotics, significantly increasing treatment costs. The healing process is also delayed, prolonging the dog's discomfort and recovery timeline.
  • When Amputation Might Become Necessary - In rare and extreme cases, if the infection is severe, untreatable, or has caused significant bone damage, limb amputation may be the only option to prevent systemic infection and further suffering. Early intervention is critical to avoid this drastic measure.

Treatment Options for Staph Infection Post-TPLO Surgery

Antibiotic Therapy

Common antibiotics for Staph infections include Clindamycin and Cephalexin, but resistant strains like MRSP require targeted antibiotics based on culture and sensitivity testing. If standard treatments fail, fluoroquinolones or chloramphenicol may be necessary. Completing the full antibiotic course is essential to prevent recurrence and resistance. Improper use of antibiotics can worsen resistance, making future infections harder to treat.

Surgical Interventions

If the infection is severe or antibiotics fail, surgical debridement is required to remove infected tissue and biofilm. In persistent infections, implant removal or revision surgery may be necessary. Surgeons may use antibiotic-impregnated beads to deliver localized medication directly to the infected site. This approach helps manage deep infections while preserving limb function, reducing the need for implant removal.

Supportive Care & Wound Management

Topical treatments like chlorhexidine and silver-based dressings help control bacterial growth at the incision. Proper wound cleaning, bandaging, and preventing licking are essential for recovery. Pain management with NSAIDs or opioids reduces discomfort, while anti-inflammatory medications control swelling. Supportive care ensures healing and prevents the infection from worsening or spreading further.

Why Early Detection and Intervention Are Crucial

Early detection and intervention are essential in preventing serious complications from Staph infections after TPLO surgery. The longer an infection goes untreated, the more likely it is to spread and cause severe complications such as osteomyelitis (bone infection), implant failure, or systemic illness. Timely treatment helps limit the damage, reduce recovery time, and avoid costly surgical interventions.

How Early Treatment Prevents Serious Complications - When infections are caught early, antibiotics can effectively control the bacteria before it forms a biofilm on the implant, making it resistant to treatment. Early intervention reduces the chances of bone destruction, chronic infections, and the need for implant removal or amputation.

When to Consult a Vet Immediately - If your dog shows any signs of infection, such as increased swelling, redness, warmth, or pus at the incision site, limping, lethargy, or fever, contact your vet immediately. Foul-smelling discharge or worsening symptoms require urgent attention, as they indicate that the infection is spreading.

The Importance of Regular Follow-Ups After TPLO Surgery - Post-surgery follow-ups are crucial for monitoring the surgical site and identifying early signs of infection. Regular check-ups help ensure that any issues are detected before they develop into more severe problems, ensuring the best possible recovery and reducing the risk of complications.

How to Prevent Staph Infections After TPLO Surgery

Pre-Surgical Prevention

Preventing Staph infections starts before surgery with proper planning. The sterile surgical environment is crucial in minimizing contamination during the procedure. Surgeons should follow strict sterilization protocols to prevent bacteria from entering the wound.

For high-risk dogs, pre-operative antibiotic protocols are recommended, especially if the dog has underlying health conditions like diabetes or is older, as these factors can weaken the immune system and increase infection susceptibility.

Post-Surgical Care Guidelines

Post-surgery, wound monitoring and cleaning are essential for preventing infection. Keep the surgical site dry and clean, changing bandages as instructed. Using an e-collar (cone of shame) can help prevent your dog from licking or biting the wound, which can introduce bacteria.

Avoid exposing your dog to contaminated environments, such as dog parks, dirty floors, or areas with other animals, until the wound is fully healed. This minimizes the risk of external contamination.

Long-Term Prevention Strategies

To maintain your dog’s health after surgery, ensure they have a well-balanced diet and consider supplements that support immune function, such as omega-3 fatty acids. Regular vet checkups help monitor recovery and prevent potential infections.

Even months after surgery, look for signs like swelling, redness, or changes in behavior that could indicate infection risks. Early intervention can prevent complications and ensure your dog’s full recovery.

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Final Thoughts

Staph infections after TPLO surgery can be very serious, leading to implant failure, bone infections, and longer recovery times. Early signs like redness, swelling, or discharge around the incision should never be ignored. Quick treatment with antibiotics and, if needed, surgery is vital to avoid serious problems.

Catching these infections early is crucial to stopping them from getting worse. Noticing the signs early and getting veterinary care right away can lead to better results and lower the risk of long-term harm. Proper post-surgery care, like cleaning the wound, using e-collars, and avoiding dirty areas, is key to preventing infections.

Pet owners should actively monitor their dog’s recovery and keep up with regular vet visits. If any issues arise, consult a vet without delay. Prevention and quick action are the best ways to ensure a smooth recovery and reduce the risk of Staph infections after TPLO surgery.

FAQs

How common is a staph infection after TPLO surgery?

Staph infections after TPLO surgery are relatively uncommon but still a risk, especially in high-risk dogs. Approximately 5-10% of dogs undergoing TPLO may develop infections, with Staphylococcus pseudintermedius being the most common bacterial culprit. Proper sterile technique during surgery, post-op care, and infection prevention strategies can reduce the chances of infection.

Can a staph infection after TPLO surgery heal on its own?

A staph infection after TPLO surgery typically does not heal on its own. Bacterial infections require medical treatment, such as antibiotics, to clear up. Without proper treatment, the infection can spread, causing serious complications like bone infection or implant failure. Seeking veterinary care immediately for proper diagnosis and treatment is essential.

What happens if a TPLO infection is left untreated?

If a TPLO infection is left untreated, it can lead to severe complications such as osteomyelitis (bone infection), implant failure, or systemic illness. The infection may spread deeper, causing chronic pain and delayed healing. In some cases, untreated infections may require surgical intervention, including implant removal or even amputation in extreme situations.

How long does it take for an infection to clear up after TPLO?

The time it takes for an infection to clear up after TPLO surgery depends on the severity of the infection and treatment method. Mild infections may clear up in 2-4 weeks with antibiotics, while severe infections can take several months and may require additional surgeries. Follow-up care is crucial to monitor progress and ensure full recovery.

Are certain dog breeds more prone to infections after TPLO?

Certain dog breeds are more prone to infections after TPLO surgery due to factors like skin folds, immune system strength, or breed-specific health issues. Breeds like Bulldogs, Pugs, and Boxers with compromised immune systems or skin conditions may have a higher risk of infection. Additionally, older dogs or those with chronic conditions like diabetes are more vulnerable.

What should I do if my dog’s TPLO incision looks infected?

If your dog’s TPLO incision looks infected, such as showing redness, swelling, pus, or a foul odor, you should consult your vet immediately. Early intervention with antibiotics or surgical debridement is essential to prevent the infection from spreading. Avoid letting your dog lick the wound and keep the incision clean while awaiting professional care.

Can a TPLO plate be removed if it causes infection?

Yes, a TPLO plate can be removed if it causes infection. In cases where the infection is persistent or deep, or if the implant becomes loose or infected, removal of the plate may be necessary to eliminate the source of the infection. The veterinarian will assess the situation and determine whether removal or revision surgery is the best option for recovery.

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Step #1

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Ensuring a clean surgical field starts with proper skin preparation. This video demonstrates the best practices for:

  • Shaving the patient – Achieving a close, even shave while minimizing skin irritation
  • The Dirty Scrub – The initial skin prep step to remove surface debris and reduce bacterial load before the sterile scrub.

Following these techniques helps reduce infection risk and improve surgical outcomes. Watch the video to see how it’s done effectively!

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Many surgeons are shocked to find out that their patients are not protected from biofilms and resistant bacteria when they use saline and post-op antibiotics.

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Why leave these risks and unmanaged?  Just apply Simini Protect Lavage for one minute. Biofilms and resistant bacteria can be removed, and you can reduce two significant sources of infection.

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Preventing surgical infections is critical for patient safety and successful outcomes. This course covers:

  • Aseptic techniques – Best practices to maintain a sterile field.
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