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TPLO Incision Infection? Symptoms & Prevention

TPLO Incision Infection? Symptoms & Prevention

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Worried about a TPLO incision infection? Learn the symptoms, causes, and best prevention tips to keep your dog’s recovery smooth and infection-free

By 

Sustainable Vet Group

Updated on

March 5, 2025

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TPLO (Tibial Plateau Leveling Osteotomy) surgery is a common procedure to stabilize a dog's knee after a cranial cruciate ligament (CCL) rupture. It involves cutting and repositioning the tibia to reduce strain on the ligament, allowing for better joint function. Like any surgery, TPLO has a risk of complications, with incision infections being a primary concern.

Infections can happen due to bacterial contamination during surgery, improper post-op care, excessive licking or chewing of the incision, or underlying conditions like diabetes or a weakened immune system. Signs of infection include redness, swelling, warmth, discharge, and delayed healing.

The risk of infection after TPLO is relatively low, occurring in about 3-10% of cases. Factors like surgical technique, sterile conditions, and strict post-operative management greatly affect the outcome. Early detection and quick treatment with antibiotics and wound care are crucial to prevent complications and ensure a successful recovery.

Symptoms and Warning Signs of TPLO Incision Infection

Recognizing the symptoms of an infection early is crucial for preventing complications after TPLO (Tibial Plateau Leveling Osteotomy) surgery. Infections can range from mild to severe, potentially affecting healing and the long-term success of the procedure. Understanding the difference between early and advanced signs can help ensure timely intervention.

Early Signs of Infection

In the initial stages, an infection may present with mild symptoms that can sometimes be mistaken for normal healing. These include:

  • Redness and swelling around the incision site, which may be slightly warm to the touch.
  • Mild pain or tenderness, which persists beyond the expected post-surgical discomfort.
  • Clear or slightly yellow discharge, which may indicate the presence of bacteria.

If detected at this stage, infections are often manageable with topical treatments, antibiotics, and proper wound care.

Advanced Signs of Infection

As an infection worsens, more severe symptoms may develop, indicating deeper tissue involvement and potential systemic infection. These include:

  • Thick, pus-like discharge from the incision, often accompanied by a foul odor.
  • Significant swelling and warmth, which may extend beyond the incision area.
  • Fever and lethargy, as the body mounts an immune response.
  • Increased lameness or reluctance to bear weight, signaling pain or joint involvement.

Advanced infections require urgent veterinary care, as untreated cases can lead to delayed healing, implant complications, or systemic illness. Immediate intervention, such as antibiotics, wound debridement, or even surgical revision, may be necessary.

Monitoring the incision closely in the weeks following TPLO surgery is essential. Any changes in the wound’s appearance, excessive discomfort, or behavioral changes in your dog should be reported to a veterinarian promptly to prevent complications.

Causes of TPLO Incision Infection

A TPLO (Tibial Plateau Leveling Osteotomy) incision infection can occur due to various factors, either during the surgery or in the post-operative recovery period. Identifying and minimizing these risks is essential for ensuring a smooth healing process.

Bacterial Contamination During or After Surgery

Despite strict sterile protocols, bacteria can sometimes enter the surgical site during the procedure. This can happen due to contamination from the skin, surgical instruments, or even the surrounding environment. Post-operatively, improper wound care or exposure to unclean surfaces can introduce bacteria, increasing infection risk.

Poor Post-Op Wound Care

Proper post-operative care is critical to prevent infection. Failure to keep the incision clean and dry, skipping prescribed antibiotics, or neglecting follow-up visits can allow bacteria to proliferate. Owners must follow all veterinary instructions carefully, including cleaning protocols and medication administration.

Licking or Chewing the Incision Site

Dogs instinctively lick their wounds, which can introduce bacteria from their mouths into the incision. Excessive licking or chewing can also cause trauma to the site, delaying healing. The use of an Elizabethan collar (E-collar) or medical pet shirt is essential to prevent self-inflicted wound contamination.

Moisture Buildup Around the Incision

A damp environment around the incision can promote bacterial growth. Moisture can accumulate from bathing, wet bedding, or excessive sweating, making it essential to keep the area dry until fully healed.

Underlying Health Conditions

Dogs with pre-existing conditions such as diabetes, Cushing’s disease, or immune disorders have a higher risk of infection due to impaired wound healing. Such cases require extra vigilance in monitoring for signs of infection.

Implants and Their Role in Infection Risk

The metal implants used in TPLO surgery can serve as a surface for bacterial adhesion. If bacteria form a biofilm on the implant, it can lead to a deep-seated infection that may require implant removal or surgical revision.

To minimize this risk, many surgeons use Simini Protect Lavage, a non-antibiotic surgical lavage designed to reduce bacterial contamination and prevent biofilm formation. Unlike traditional solutions, Simini Protect Lavage actively disrupts bacterial adhesion, helping to lower infection risks without contributing to antibiotic resistance. Its use in TPLO and other orthopedic procedures has shown promising results in enhancing post-surgical outcomes.

Preventing infection requires a combination of strict surgical protocols, diligent post-op care, and close monitoring of the incision site for any signs of complications.

How TPLO Infections Are Diagnosed

Diagnosing a TPLO incision infection requires a thorough evaluation by a veterinarian to determine the severity and appropriate treatment plan. Early detection is key to preventing complications such as delayed healing, deep tissue infections, or implant failure.

Physical Examination

The first step in diagnosing an infection is a detailed physical examination of the incision site. The veterinarian will check for common signs of infection, including:

  • Redness and swelling around the incision.
  • Abnormal discharge (pus, thick yellow fluid, or foul-smelling secretions).
  • Increased warmth in the surrounding tissue.
  • Pain response when the area is gently palpated.
  • Signs of systemic illness, such as fever or lethargy.

Diagnostic Tests

If an infection is suspected, further diagnostic tests help confirm the presence and extent of the infection.

  • Wound Culture and Sensitivity Test - A swab of the incision site is collected to identify the specific bacterial strain causing the infection. This helps determine the most effective antibiotic treatment.
  • Complete Blood Count (CBC) - Blood tests check for elevated white blood cell counts (WBCs), which indicate an immune response to infection. Other markers, such as increased neutrophils, may suggest a bacterial infection.
  • X-rays or Advanced Imaging - If the infection has progressed or involves the surgical implants, X-rays or ultrasound imaging may be used to assess deep tissue involvement. In some cases, an infection can lead to osteomyelitis (bone infection) or implant loosening, requiring further surgical intervention.

Prompt and accurate diagnosis ensures that treatment is initiated quickly, reducing the risk of complications and improving the chances of a full recovery.

Potential Complications of an Untreated TPLO Incision Infection

If a TPLO incision infection is left untreated, it can lead to serious complications that may jeopardize the success of the surgery and the dog’s long-term mobility. Early intervention is crucial to prevent these risks.

Implant Failure and the Need for Removal or Revision Surgery

TPLO surgery involves the placement of metal implants (plates and screws) to stabilize the tibia. If bacteria colonize the implant, they can form a biofilm, making the infection difficult to treat with antibiotics alone. This can lead to implant loosening or failure, requiring removal or revision surgery to replace the affected hardware. A second surgery increases recovery time and risk of further complications.

Read more about - Signs of TPLO Failure in Dogs & When to See a Vet

Deep Bone Infection (Osteomyelitis)

When an infection spreads beyond the incision site into the bone tissue, it can cause osteomyelitis, a severe and persistent infection. Bone infections are challenging to treat and often require long-term antibiotics, surgical debridement, or even partial bone removal in extreme cases. Osteomyelitis can significantly delay healing and may compromise limb function.

Delayed Healing, Prolonged Pain, and Lameness

An untreated infection slows down wound healing, leading to persistent inflammation, chronic pain, and prolonged lameness. Infections interfere with the body’s natural healing process, increasing the risk of poor scar formation and weakening the stability of the joint. This can result in long-term mobility issues, affecting the dog’s quality of life.

Risk of Systemic Infection (Sepsis)

If bacteria enter the bloodstream, the infection can become systemic, leading to sepsis, a life-threatening condition. Sepsis causes widespread inflammation, organ dysfunction, and severe illness. Immediate hospitalization, intravenous antibiotics, and aggressive supportive care are required in such cases.

Preventing complications requires early diagnosis, strict post-op care, and immediate treatment of any signs of infection to ensure a smooth recovery.

Treatment Options for TPLO Incision Infections

A TPLO incision infection requires prompt and appropriate treatment to prevent complications and ensure proper healing. The treatment plan depends on the severity of the infection, the presence of bacterial colonization on the implants, and the dog’s overall health.

Antibiotic Therapy

Antibiotics are the first line of treatment for a TPLO incision infection. The choice of antibiotic depends on wound culture and sensitivity testing, ensuring effective targeting of the bacteria.

  • Oral antibiotics (e.g., cephalexin, clindamycin, or enrofloxacin) are commonly prescribed for mild to moderate infections.
  • Topical antibiotics (e.g., silver sulfadiazine or mupirocin) may be used to manage surface-level infections.
  • If the infection is deep-seated or spreading, intravenous (IV) antibiotics may be required for better systemic control.

Wound Cleaning and Care

Proper wound care helps clear bacteria and promote healing. This includes:

  • Cleaning the incision with veterinary-approved antiseptic solutions (chlorhexidine or diluted povidone-iodine).
  • Avoiding excessive moisture buildup around the wound.
  • Preventing licking or chewing with an Elizabethan collar (E-collar) or medical pet shirt.
  • Ensuring the bandage (if used) is clean and changed as recommended by the veterinarian.

Pain Management

Infections cause inflammation and discomfort, so pain relief is an important part of treatment.

  • Non-steroidal anti-inflammatory drugs (NSAIDs) such as carprofen or meloxicam may be prescribed to reduce pain and swelling.
  • If severe discomfort persists, stronger pain relievers may be necessary.

Surgical Intervention

For infections that do not respond to antibiotics or involve the implants, surgical intervention may be needed:

  • Flushing and debridement – The vet may clean and remove infected tissue under anesthesia to prevent further bacterial spread.
  • Implant removal or revision – If bacteria have colonized the TPLO plate and screws, implant removal may be necessary, followed by a prolonged course of antibiotics to clear the infection.

Timely and appropriate treatment is essential to prevent long-term complications and ensure a smooth recovery. Close veterinary supervision and adherence to post-op care instructions significantly improve outcomes.

When to Call Your Veterinarian

Recognizing the signs of a TPLO incision infection early and seeking veterinary care promptly can prevent serious complications. Certain symptoms indicate the need for immediate medical attention:

  • Excessive swelling, redness, or warmth around the incision.
  • Thick, pus-like discharge or a foul odor from the wound.
  • Persistent pain or worsening lameness beyond the expected healing period.
  • Fever, lethargy, or loss of appetite, which may indicate a systemic infection.
  • Sudden changes in behavior, such as reluctance to move or increased sensitivity around the incision.

How Quickly Should an Infection Be Addressed?

If you notice any signs of infection, contact your veterinarian immediately. Mild infections caught early may be treated with antibiotics and wound care, but delays in treatment can lead to deeper infections, increasing the risk of implant failure or systemic illness.

What to Expect During a Vet Visit

Your veterinarian will:

  • Perform a physical examination of the incision.
  • Conduct diagnostic tests (wound cultures, blood tests, or X-rays) if needed.
  • Prescribe antibiotics or pain medication based on the infection’s severity.
  • Recommend wound cleaning protocols or, in severe cases, surgical intervention to remove infected tissue or implants.

Prompt veterinary care ensures a smoother recovery and reduces the risk of long-term complications.

Preventing TPLO Incision Infections

Preventing infection after TPLO surgery is crucial for ensuring a smooth recovery and avoiding complications. Proper post-operative care significantly reduces the risk of infection and promotes faster healing.

Proper At-Home Wound Care Routine

A clean and well-maintained incision site is essential for preventing bacterial growth. Follow these steps to ensure proper wound care:

  • Inspect the incision daily for redness, swelling, or discharge.
  • Use vet-approved antiseptic solutions if cleaning is necessary.
  • Avoid touching the wound with unclean hands to prevent contamination.
  • Follow the prescribed antibiotic regimen to eliminate any potential bacterial infections.

Importance of E-Collars to Prevent Licking

Dogs instinctively lick wounds, but their mouths contain bacteria that can introduce infection.

  • An Elizabethan collar (E-collar) or medical pet shirt should be used at all times until the incision fully heals.
  • Even brief periods of licking can introduce bacteria, delaying healing and increasing infection risk.

Keeping the Incision Dry and Clean

Moisture creates an ideal environment for bacterial growth, so it’s important to:

  • Prevent the incision from getting wet—no bathing or swimming until cleared by the vet.
  • Keep the bedding clean and dry to avoid contamination.
  • If the incision gets wet, gently pat it dry with a clean, soft cloth.

Following Post-Op Care Instructions Strictly

Veterinary post-op guidelines should be followed precisely, including:

  • Restricted activity to prevent excessive movement that could stress the incision.
  • Proper medication schedules, including antibiotics and pain relievers.
  • Scheduled follow-up visits to monitor healing progress.

Monitoring for Any Early Signs of Infection

Even with proper care, infections can still develop. Watch for:

  • Redness, swelling, or discharge from the incision.
  • Excessive licking or signs of discomfort around the area.
  • Changes in behavior, such as lethargy or reluctance to move.

By taking proactive steps in at-home care, pet owners can significantly reduce the chances of post-operative infections and support a successful TPLO recovery.

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Conclusion

A TPLO incision infection can slow down healing and cause serious problems if not treated. It's important to notice early signs of infection, like redness, swelling, discharge, or increased pain, to prevent further issues. Quick veterinary care can greatly improve recovery results.

Proper post-operative wound care, such as keeping the incision clean and dry, using an E-collar to prevent licking, and following all prescribed medications, helps reduce the risk of infection. Watching for any changes in the incision site or behavior allows for early action if needed.

If an infection happens, quick diagnosis and treatment with antibiotics, wound care, or surgery ensure the best recovery possible. By being watchful and proactive in post-op care, pet owners can support a smooth healing process and help their dog regain mobility safely.

FAQs

How do I know if my TPLO incision is infected?

A TPLO incision infection may show signs such as redness, swelling, warmth, and abnormal discharge (yellow, pus-like, or foul-smelling fluid). The incision may become painful, and your dog might show increased licking, lethargy, fever, or reluctance to walk. If you notice any of these symptoms, contact your veterinarian immediately for evaluation and treatment.

How do you treat a TPLO infection?

Treatment depends on the severity of the infection. Mild cases may be managed with oral antibiotics and wound cleaning, while severe infections might require intravenous antibiotics, wound flushing, or even implant removal if bacteria form a biofilm. Pain management and restricted movement are also essential for recovery. Early treatment ensures the best outcomes and prevents complications like deep bone infections or implant failure.

What to do if my dog's incision is infected?

If you suspect an infection, contact your veterinarian immediately. Avoid cleaning the wound with unapproved solutions, and prevent your dog from licking the incision by using an E-collar or protective covering. The vet may prescribe antibiotics, pain relief, or wound debridement depending on the infection's severity. Delaying treatment can worsen the infection and lead to complications.

How common is infection after TPLO surgery?

Infections after TPLO surgery are relatively uncommon, occurring in about 3-10% of cases. The risk increases with factors like poor post-op care, excessive licking, moisture exposure, or underlying health issues such as diabetes or immune suppression. Following strict wound care protocols and monitoring for early signs of infection significantly reduces the risk.

What is the infection rate for TPLO?

The infection rate for TPLO surgery ranges from 3-10%, depending on factors such as surgical technique, sterility, and post-operative care. Using advanced infection prevention methods, such as Simini Protect Lavage, proper antibiotic use, and strict wound monitoring, can help minimize infection risks. Prompt intervention at the first sign of infection is essential.

What does the start of an infected incision look like?

The early signs of an infected TPLO incision include increased redness, mild swelling, warmth, and clear to yellow discharge. The area may become more painful than expected during normal healing, and your dog may lick or chew the incision excessively. If left untreated, symptoms can worsen, leading to pus formation, odor, and systemic illness. Any suspicious changes should be evaluated by a veterinarian immediately.

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Step #1

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Ensuring a clean surgical field starts with proper skin preparation. This video demonstrates the best practices for:

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